Recent Publications

*Hovey, L.,  *Fowler, C.A., Mahling, R., Lin, Z., Miller, M.S. Marx, D.C., Yoder, J.B., Kim, E.H., Tefft, K.M., Waite, B.C., Feldkamp, M.D., Yu, L., Shea, M.A.  (2017)  Calcium Triggers Reversal of Calmodulin on Nested Anti-Parallel Sties in the IQ Motif of the Neuronal Voltage-Dependent Sodium Channel NaV1.2  (PDB ID:  2M5E). Biophysical Chemistry 224:1-19 (

Feldkamp, M.D., Gakhar, L., Pandey, N. and Shea, M.A. (2015) Stuctural Insights into Molecular Specificity of Trifluoperazine Binding to Calcium-Saturated Calmodulin and the Role of Met144. Proteins: Structure, Function and Bioinformatics. PDB ID - 4RJD (

Newman, R.A., Sorensen, B.R., Kilpatrick, A.M., Shea, M.A. (2014) Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1).
Biophys Chem. 193-194:35-49. [DOI: 10.1016/j.bpc.2014.07.004] (

Wang, X., Boyken, S.E., Hu, J., Xu, X., Rimer, R.P., Shea, M.A., Shaw, A.S., Andreotti, A.H., and Huang, Y.H. (2014) Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. Sci. Signal 7:337. [DOI: 10.1126/scisignal.2005147] (

Shea, M.A., Correia, J.J., Brenowitz, M.D. (2011) Introduction: Twenty Five Years of the Gibbs Conference on Biothermodynamics. Biophysical Chemistry 159:1-5. (

Evans, T.I.A., Hell, J.W., Shea, M.A. (2011) Thermodynamic Linkage between Calmodulin Domains Binding Calcium and Contiguous Sites in the C-Terminal Tail of Ca V1.2. Biophysical Chemistry 159:172-187. (

Feldkamp, M.D., Yu, L., Shea, M.A. (2011) Structural Determinants of Apo Calmodulin Binding to the IQ-Motif of the NaV1.2 Voltage-Dependent Sodium Channel. Structure 19:733-47.

O'Donnell, S.E., Yu, L., Fowler, C.A., Shea, M.A. (2011) Recognition of Beta-Calcineurin by the Domains of Calmodulin. Proteins: Structure, Function, Bioinformatics 79:765-786.

Feldkamp, M.D., O'Donnell, S.E., Yu, L., Shea, M.A. (2010) Allosteric Effects of the Anti-Psychotic Drug Trifluoperazine on the Energetics of Calcium Binding by the Calmodulin. Proteins: Structure, Function, Bioinformatics 78: 2265-2282 (

O'Donnell, S. E., Newman, R.A.., Witt, T.J., Hultman, R., Froehlig, J., Christensen, A.P., Shea, M.A (2009) Thermodynamics and Conformational Change Governing Domain-Domain Interactions of Calmodulin. in Methods in Enzymology 466: 503-526 Edited by Ackers, G.K., Holt, J., Johnson, M.L. (

Evans, T.I.A. and Shea, M.A. (2009) Energetics of Calmodulin Domain Interactions with the Calmodulin Binding Domain of CaMKII. Proteins: Structure, Function, Bioinformatics 76:47-61. (

O'Donnell, S. E., Newman, R.A., Witt, T.J., Hultman, R., Froehlig, J., Christensen, A.P., Shea, M.A. (2009) Thermodynamics and Conformational Change Governing Domain-Domain Interactions of Calmodulin in Methods in Enzymology. 466: 503-526 (Johnson, M.L., Holt, J., Ackers, G.K., editors)

Erickson, J.R., Joiner, M.L., Guan X., Kutschke, W., Yang, J., Oddis, C.V., Bartlett, R.K., Lowe, J.S., O'Donnell, S., Aykin-Burns, N., Zimmerman, M.C., Zimmerman, K., Ham, A.L., Weiss, R.M., Spitz, D.R., Shea, M.A., Colbran, R.J., Mohler, P.J., Anderson, M. (2008) A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation. Cell 133: 462-474 (

Theoharis, N.T., Sorensen, B.R., Shea, M.A. (2008) Neuronal Voltage-Dependent Sodium Channel Type II (NaV1.2) IQ Motif Lowers Calcium Affinity of the C-domain of Calmodulin. Biochemistry 47: 112-123 (

Newman, R.A., VanScyoc, W.S., Jaren, O.R., and Shea, M.A. (2008) Domain-Specific Interactions of Calmodulin Bound to Melittin Preferentially Increases Clacium Affinity of Sites I and II. Proteins: Structure, Function, Bioinformatics 71:1792-812. (

Akyol, Z., Gakhar, L., Sorensen, B.R., Hell, J.W., and Shea, M.A. (2007) The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains. Structure 15: 1603-1617 (

Li, Q., Cooper, J.J., Altwerger, G.H., Feldkamp, M.D., Shea, M.A., and Price, D.P. (2007) HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells. Nucleic Acids Research 35: 2503?2512. (

Merrill, M.A., Malik, Z., Akyol, Z., Bartos, J.A., Leonard, A.S., Hudmon, A., Shea, M.A. and Hell, J.W. (2007) Displacement of a-Actinin from the NMDA Receptor NR1 C0 Domain by Ca2+/Calmodulin Promotes CaMKII Binding. Biochemistry 46:8485-97 (

VanScyoc, W.S., Newman, R.A., Sorensen, B.R., Shea, M.A. (2006) Calcium Binding to Paramecium Calmodulin Mutants Having Domain?Specific Effects on Regulation of Ion Channels. Biochemistry 45: 14311-14324 (

Ross J.B.A., Laws W., Shea M.A. (2006) Intrinsic Fluorescence in Protein Structure Analysis. in Protein Structures: Methods in Protein Structure and Structure Analysis: Luinescence Spectroscopy and Circular Dichroism, Eds. VN Uversky, EA Permyakov, Nova Science Publishers, Inc., New York. 55-72 ISBN 1600214045 (

Wang, B., Martin, S.R, Newman, R.A., Hamilton, S.L., Shea, M.A., Bayley, P.M., and Beckingham, K. (2004) Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila. Protein Science 13: 3285-3297 (

Hines, R., Sorensen, B.R., Shea, M.A., Maury, W. (2004) PU.1 Binding to ets Motifs within the Equine Infectious Anemia Virus Long Terminal Repeat (LTR) Enhancer: Regulation of LTR Activity and Virus Replication in Macrophages. J. Virology 78: 3407?3418. (

Akyol, Z., Bartos, J., Jaren, O.R., Faga, L., Shea, M.A. and Hell, J.? (2004) Apo-Calmodulin Binds with its COOH-terminal Domain to the N-methyl-D-aspartate Receptor NR1 C0 Region. J. Biol. Chem. 279(3): 2166-2175. (

Faga, L.A., Sorensen, B.R., VanScyoc, W.S., and Shea, M.A. (2003) Basic Interdomain Boundary Residues in Calmodulin Decrease Calcium Affinity of Sites I and II by Stabilizing Helix-Helix Interactions. Proteins: Structure, Function & Genetics 50: 381-391. (

Leonard, A.S., Bayer, K-U, Merrill, M., Shea, M.A., Schulman, H., and Hell, J.W. (2002) Regulation of CaMKII Docking to NMDA Receptors by Calcium/Calmodulin and a-Actinin. J. Biol. Chem. 277: 48441-48448 (

Jaren, O.R., Kranz, J.K., Sorensen, B.R., Wand, A.J., Shea, M.A. (2002) Calcium-Induced Conformational Switching of Paramecium Calmodulin: Changes in the Protein Backbone Observed by Heteronuclear NMR Studies. Biochemistry 41: 14158-14166. (

VanScyoc, W.S., Sorensen, B.R., Rusinova, E., Laws, W., Ross, J.B.A., and Shea, M.A. (2002) Domain-Specific Fluorescence of Calmodulin: Phenylalanine Reports Exclusively on Calcium Binding to the N-Domain. Biophysical Journal 83: 2767-2790. (

Xiong, L-W, Newman, R.A., Rodney, G.C., Thomas, O., Zhang, J-Z, Persechini, A., Shea, M.A., and Hamilton, S.L. (2002) Lobe Dependent Regulation of Ryanodine Receptor Type One by Calmodulin. J. Biol. Chem. 277:40862-40870. (

Sorensen, B.R., Faga, L.A., Hultman, R., Shea, M.A. (2002) Interdomain Linker Increases Thermostability and Decreases Calcium Affinity of Calmodulin N-Domain. Biochemistry 41: 15-20. (

Sun, H., Yin, D., Coffeen, L.A., Shea, M.A., and Squier, T.C. (2001) Mutation of Tyr138 Disrupts the Structural Coupling Between the Opposing Domains in Vertebrate Calmodulin. Biochemistry 40: 9605-9617. (

VanScyoc, W. and Shea, M.A. (2001) Phenylalanine fluorescence studies of calcium binding to N-domain fragments of Paramecium calmodulin mutants show increased calcium affinity correlates with increased disorder. Protein Science 10:1758-1768. (

Sorensen, B.R., Eppel, J.T., Shea, and M.A. (2001) Paramecium Calmodulin Mutants Defective in Ion Channel Regulation Associate with Melittin in the Absence of Calcium but Require it for Tertiary Collapse. Biochemistry 40:896-903. (